The field of dosage form designing and pharmaceutical modeling revels in the development of dosage forms that enhance bioavailability, in vivo stability, intestinal absorption and therapeutic efficacy on the whole. One such endeavor for a Novel drug delivery system is aquasome. Aquasomes are self assembling, tri-partied novel drug delivery systems that are also called as water bodies as their water like properties provides a platform for preserving the conformational integrity and bio chemical stability of bio-actives. Unique three-dimensional conformation, a freedom of internal molecular rearrangement induced by molecular interactions and a freedom of bulk movement are some of the key components of the system. Their mechanism of action is controlled by their surface chemistry as they deliver contents through combination of specific targeting, molecular shielding, and slow and sustained release process. Further due to their size and structure stability, avoid clearance by reticuloendothelial system or degradation by other environmental challenges. Structurally an aquasome comprises of a drug core situated on the outside lined by an Oligomeric carbohydrate nanocrystalline film. Another key feature is the presence of calcium phosphate di-hydrate, which is unstable and converts to hydroxyapatite upon prolong storage and is used for self assembling of the dosage form. The present paper reviews the dosage form pharmaceutically as well as enumerates biopharmaceutical applications and impinges the requirement of aquasomal drug delivery.
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